FRANCE: This is the crackle of neural activity that allows a fruit-fly (Drosophila melanogaster) larva to crawl backwards: a flash in the brain and a surge that undulates through the nervous system from the top of the larva’s tiny body to the bottom. When the larva moves forwards, the surge flows the other way.
The video — captured almost at the resolution of single neurons — demonstrates the latest development in a technique to film neural activity throughout an entire organism. The original method was invented by Philipp Keller and Misha Ahrens at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia. The researchers genetically modify neurons so that each cell fluoresces when it fires; they then use innovative microscopy that involves firing sheets of light into the brain to record that activity.
In 2013, the researchers produced a video of neural activity across the brain of a (transparent) zebrafish larva1. The fruit-fly larva that is mapped in the latest film, published in Nature Communications on 11 August2, is more complicated. The video shows neural activity not just in the brain, but throughout the entire central nervous system (CNS), including the fruit-fly equivalent of a mammalian spinal cord. And unlike the zebrafish, the fruit fly’s nervous system is not completely transparent, which makes it harder to image.
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